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Thymosin Beta-4

Also known as: Tβ4, TB4, Thymosin β4

Evidence: ModerateRisk: Unknown
Administration:šŸ’‰ SubQšŸ’‰ IM

Overview

A naturally occurring 43-amino acid peptide present in high concentrations in blood platelets, wound fluid, and many tissues. It plays a role in tissue repair, wound healing, and inflammation regulation. TB-500 is its better-known synthetic counterpart used in research and clinical settings.

Benefits

  • āœ“tissue repair support
  • āœ“wound healing
  • āœ“injury recovery
  • āœ“joint and tendon health
  • āœ“anti-inflammatory effects

Potential Side Effects

  • •injection site reactions (redness, swelling)
  • •headache
  • •fatigue
  • •nausea
  • •temporary soreness

Who Should Avoid

  • ⚠pregnancy or breastfeeding
  • ⚠active cancer or cancer history without oncologist approval
  • ⚠severe autoimmune conditions without medical supervision
  • ⚠known allergies to thymosin peptides

Interactions & Precautions

Interactions are not well-documented. May affect immune response and tissue healing. Comprehensive discussion with healthcare provider required, especially for those on immunosuppressive therapy or anticoagulants.

Dosing Information from Literature

Research protocols have varied from 2-10 mg per injection, administered 1-2 times weekly. The synthetic version (TB-500) is more commonly discussed in practice. Clinical dosing standards for the natural peptide are not established.

This is descriptive information only. Always consult a licensed healthcare provider for dosing guidance.

Storage

Store unreconstituted peptide in freezer (-20°C or colder). After reconstitution, store refrigerated at 2-8°C and use within the timeframe specified by supplier (typically 2-4 weeks). Protect from light.

Last reviewed: 11/13/2025