Semax
Also known as: ACTH(4-10)
Overview
A synthetic peptide developed in Russia based on a fragment of ACTH (adrenocorticotropic hormone). It has been approved in Russia as a nootropic and neuroprotective agent, though it remains experimental in most other countries.
Benefits
- ✓cognitive enhancement
- ✓focus and memory
- ✓neuroprotection
- ✓mental clarity
Potential Side Effects
- •nasal irritation (nasal form)
- •headache
- •restlessness or overstimulation
- •changes in sleep patterns
Who Should Avoid
- ⚠pregnancy or breastfeeding
- ⚠severe mental health conditions without medical oversight
- ⚠individuals with anxiety disorders
- ⚠cardiovascular conditions without clearance
Interactions & Precautions
Limited interaction data outside of Russian research. May interact with stimulants, nootropics, and psychiatric medications. May affect stress hormone pathways.
Dosing Information from Literature
Russian protocols use nasal administration of 0.5-1 mg per day divided into 2-3 doses. Various concentrations exist (0.1%, 1%). Western clinical validation is lacking.
This is descriptive information only. Always consult a licensed healthcare provider for dosing guidance.
Storage
Store unreconstituted peptide in freezer (-20°C or colder). After reconstitution, store refrigerated and use within 2-3 weeks. Nasal formulations may have different storage requirements.