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Oxytocin

Also known as: Pitocin, OT

Evidence: ModerateRisk: Moderate
Administration:👃 Nasal💉 SubQ

Overview

A naturally occurring neuropeptide and hormone produced in the hypothalamus. It is FDA-approved for medical use in childbirth and has been researched for various psychological and social applications.

Benefits

  • social bonding
  • stress reduction
  • mood support
  • relationship enhancement

Potential Side Effects

  • nasal irritation (nasal form)
  • headache
  • nausea
  • uterine contractions (particularly in pregnancy)
  • water retention

Who Should Avoid

  • pregnancy without obstetric supervision (can induce labor)
  • breastfeeding without medical guidance
  • cardiovascular disease
  • significant hyponatremia risk

Interactions & Precautions

Can interact with medications affecting blood pressure and water balance. May potentiate vasopressin effects. Contraindicated during pregnancy except under medical supervision for labor induction.

Dosing Information from Literature

Research protocols for psychological applications have used intranasal doses of 24-40 IU. Medical obstetric use follows different protocols. Proper medical supervision essential.

This is descriptive information only. Always consult a licensed healthcare provider for dosing guidance.

Storage

Store unreconstituted peptide refrigerated at 2-8°C. After reconstitution, use immediately or store refrigerated for up to 24 hours. Nasal sprays have specific storage requirements.

Last reviewed: 11/3/2025