NAD+
Also known as: Nicotinamide Adenine Dinucleotide, NAD+ IV, NAD Plus
Overview
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in all living cells, not technically a peptide. It plays a crucial role in cellular energy production, DNA repair, and numerous metabolic processes. NAD+ levels naturally decline with age.
Benefits
- ✓cellular energy optimization
- ✓anti-aging support
- ✓metabolic health
- ✓cognitive function
- ✓DNA repair support
- ✓mitochondrial function
Potential Side Effects
- •flushing or warmth
- •nausea (especially IV/IM)
- •cramping or discomfort during IV infusion
- •headache
- •fatigue (transient)
- •injection site reactions
Who Should Avoid
- ⚠pregnancy or breastfeeding
- ⚠active malignancy without oncology clearance
- ⚠severe kidney or liver disease
- ⚠known hypersensitivity to niacin or NAD+ compounds
Interactions & Precautions
May interact with medications affecting liver metabolism. Can interact with blood pressure medications. May affect glucose metabolism - caution with diabetes medications. Discuss all supplements and medications with clinician.
Dosing Information from Literature
Oral NAD+ precursors (NMN, NR) typically use 250-1000 mg daily. Injectable NAD+ protocols vary widely from 25-100 mg subcutaneous to 250-1000 mg IV infusions. IV infusions are typically administered slowly over 2-4 hours to minimize side effects.
This is descriptive information only. Always consult a licensed healthcare provider for dosing guidance.
Storage
Store unreconstituted NAD+ powder refrigerated at 2-8°C, protected from light. After reconstitution with sterile saline or sterile water, use immediately or store refrigerated for up to 24 hours. IV formulations may have different requirements.