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MOTS-C

Also known as: Mitochondrial ORF of the 12S rRNA Type-C

Evidence: PreliminaryRisk: Unknown
Administration:💉 SubQ💉 IM

Overview

A mitochondrial-derived peptide that plays a role in metabolic regulation and cellular energy. It is a relatively new area of research exploring mitochondrial function and metabolic health.

Benefits

  • metabolic function support
  • exercise endurance
  • insulin sensitivity
  • mitochondrial health

Potential Side Effects

  • injection site reactions
  • fatigue (initial)
  • mild headache

Who Should Avoid

  • pregnancy or breastfeeding
  • active malignancy
  • severe cardiovascular disease without medical clearance
  • individuals with metabolic disorders without clinician guidance

Interactions & Precautions

Limited interaction data available. Exercise caution with diabetes medications and metabolic therapies. Discuss all medications with a clinician.

Dosing Information from Literature

Emerging research has explored doses ranging from 5-15 mg administered 2-3 times per week. Human studies are limited and protocols vary.

This is descriptive information only. Always consult a licensed healthcare provider for dosing guidance.

Storage

Store unreconstituted peptide in freezer (-20°C or colder). After reconstitution with bacteriostatic water, store refrigerated and use within 2-3 weeks.

Last reviewed: 11/3/2025