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Melanotan-2

Also known as: MT-2, MT-II, Melanotan II

Evidence: PreliminaryRisk: High
Administration:💉 SubQ

Overview

Melanotan-2 is a synthetic peptide analog of alpha-melanocyte stimulating hormone. It is often discussed for its effects on skin pigmentation and libido, though it is not approved by major regulatory agencies and safety data is limited.

Benefits

  • Skin tanning without UV exposure
  • Libido enhancement
  • Appetite suppression (secondary effect)
  • Sexual function support

Potential Side Effects

  • Nausea (especially with initial doses)
  • Flushing
  • Facial darkening or uneven pigmentation
  • Spontaneous erections (in males)
  • Increased skin moles and freckles
  • Fatigue
  • Loss of appetite

Who Should Avoid

  • Pregnant or breastfeeding individuals
  • People with a personal or family history of melanoma or other skin cancers
  • Those with cardiovascular conditions
  • Individuals with uncontrolled high blood pressure
  • Anyone with numerous moles or atypical moles (requires dermatology evaluation)
  • Those taking medications affecting skin or cardiovascular system without medical review

Interactions & Precautions

May interact with medications affecting blood pressure or cardiovascular function. Risk profile is poorly characterized. Consultation with healthcare provider is critical.

Dosing Information from Literature

Anecdotal protocols often cite 0.25-1 mg per dose, with 'loading' phases followed by maintenance. No formal clinical dosing exists. Use is not medically endorsed.

This is descriptive information only. Always consult a licensed healthcare provider for dosing guidance.

Storage

Store lyophilized powder refrigerated or frozen. After reconstitution, refrigerate and use promptly per supplier guidance.

Last reviewed: 11/2/2025