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Kisspeptin-10

Also known as: KP-10, Metastin, Kiss1

Evidence: PreliminaryRisk: Unknown
Administration:💉 SubQ💉 IM

Overview

A peptide hormone that plays a critical role in regulating reproductive hormone secretion, particularly in triggering GnRH (gonadotropin-releasing hormone) release. Research has explored its role in fertility and sexual function.

Benefits

  • reproductive hormone support
  • libido enhancement
  • fertility support
  • hypothalamic-pituitary axis optimization

Potential Side Effects

  • injection site reactions
  • hot flashes
  • headache
  • nausea
  • changes in mood

Who Should Avoid

  • pregnancy or breastfeeding
  • hormone-sensitive cancers
  • individuals with reproductive disorders without endocrine specialist guidance
  • adolescents without medical supervision

Interactions & Precautions

Very limited interaction data. May affect reproductive hormones including LH, FSH, and sex hormones. Comprehensive endocrine evaluation essential before use. May interact with hormonal therapies.

Dosing Information from Literature

Clinical research has explored intravenous doses in the microgram range for studying reproductive function. Subcutaneous protocols are less established. Human data is limited.

This is descriptive information only. Always consult a licensed healthcare provider for dosing guidance.

Storage

Store unreconstituted peptide in freezer (-20°C or colder). After reconstitution with bacteriostatic water, store refrigerated and use within 1-2 weeks.

Last reviewed: 11/3/2025