← Back to Library

GHK-Cu

Also known as: Copper Peptide, GHK-Copper

Evidence: ModerateRisk: Low
Administration:🧴 Topical💉 SubQ

Overview

A copper-binding peptide naturally found in human plasma, saliva, and urine. It has been extensively studied for skin health and wound healing, with some topical formulations available commercially.

Benefits

  • skin rejuvenation
  • wound healing
  • collagen production
  • hair health

Potential Side Effects

  • skin irritation (topical)
  • injection site reactions (injectable)
  • copper sensitivity (rare)

Who Should Avoid

  • pregnancy or breastfeeding
  • copper metabolism disorders (Wilson's disease)
  • copper allergies or sensitivities

Interactions & Precautions

May interact with copper supplements or medications affecting copper metabolism. Generally well-tolerated topically. Discuss with clinician if using other copper-containing products.

Dosing Information from Literature

Topical formulations typically use 0.05-2% concentrations. Subcutaneous injection protocols in research have varied from 1-10 mg, but topical use is more common and established.

This is descriptive information only. Always consult a licensed healthcare provider for dosing guidance.

Storage

Store unreconstituted peptide in freezer (-20°C or colder). After reconstitution, store refrigerated and use within 2-3 weeks. Protect from light.

Last reviewed: 11/3/2025